14.1 Human Chromosomes
14.2 Human Genetic Disorders
14.3 Studying the Human Genome
THE CROOKED CELL
When Ava visited her Uncle Eli in the hospital, he appeared tired and pale. He complained of sharp pains in his bones. “I've got sickle cell disease,” Uncle Eli explained, short of breath. “I just hope it doesn't run in your side of the family.”
That evening, Ava searched the Internet for information about her uncle's disease. She saw photos of red blood cells shaped like the letter C—a far cry from the healthy, round blood cells of a normal individual. Ava learned that these sickle-shaped cells are rigid and sticky. In blood vessels, they form clumps that can block blood flow and even cause organ damage. “Am I at risk?” Ava wondered. To find out, she would need to investigate her family history—and her own cells. As you read this chapter, look for clues that would help Ava discover whether she might carry sickle cell trait. Then, solve the mystery.
Never Stop Exploring Your World.
Finding out about Ava's risk of sickle cell disease is only the beginning. Take a video field trip with the ecogeeks of Untamed Science to see where the mystery leads.